Retinal Pigment Epithelium Is Protected Against Apoptosis by B-Crystallin

نویسندگان

  • Claudia S. Alge
  • Siegfried G. Priglinger
  • Aljoscha S. Neubauer
  • Anselm Kampik
  • Markus Zillig
  • Hans Bloemendal
  • Ulrich Welge-Lussen
چکیده

PURPOSE. The degeneration of retinal pigment epithelial (RPE) cells is considered to be a crucial event in the pathophysiology of age-related macular degeneration (AMD). Cumulative oxidative damage has been implicated in the development of the changes seen in AMD. The present study was undertaken to evaluate the expression of the small heat shock protein Bcrystallin in the RPE in response to oxidative stress and to explore whether B-crystallin expression confers an antiapoptotic cytoprotective effect on RPE cells.

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تاریخ انتشار 2002